Research portfolio

The VBOHC research agenda asks whether structured, dosed, and instrumented environmental exposure, delivered under protocol, produces changes in disease trajectory

➡Clinical Research

➡Mechanistic Research

➡Environmental Exposure

➡Disease Trajectory

➡Outcomes Research

➡Health Economics

Current studies

Protocols and proposed studies.

Final design parameters set in an IRB-approved protocol.

Recruitment: When a study opens, it will be listed here with its IRB of record, principal investigator, eligibility criteria, and registration number.

Register interest in future research.

OMOHC-PAIN MOB Structured Outdoor Movement in Chronic Pain and Mobility Is structured outdoor movement, as part of a multimodal program, associated with greater improvement in pain interference and function than an activity-matched comparison? ➡Study details
OMOHC-SR-2026-001 Systematic Review of Nature-Based and Outdoor Clinical Interventions What does the existing literature support, and where are the gaps, for outdoor and nature-based clinical interventions? ➡Study details
OMOHC-ANXCV Environmental Exposure, Anxiety, and Cardiovascular Regulation Is structured outdoor exposure associated with measurable changes in anxiety, autonomic regulation, and cardiovascular markers? ➡Study details
VBOHC Delphi Protocol Delphi Consensus on the VBOHC Core Outcome Set Which of 70 candidate measures should form a standard core outcome set for outdoor clinical research? ➡Study details
OMOHC-DEPMET Nature Dose in Depression and Metabolic Health Does a prescribed nature dose change depressive symptoms and metabolic markers beyond what physical activity alone explains? ➡Study details
Intergenerational Stress and Biological Regulation How do family systems, chronic stress, environmental exposure, and autonomic regulation relate to biological outcomes? ➡Study details
OMOHC-NEUROCOG Environmental Exposure and Neurocognitive Health Is structured environmental exposure associated with changes in cognitive function and stress regulation? ➡Study details
Nature Exposure and Disease Trajectory: National Outcomes Registry Is measurable environmental exposure associated with long-term changes in disease-related outcomes, utilization, and cost? ➡Study details 
ALL               CHRONIC PAIN/MSK              BEHAVIORAL HEALTH              CARDIOMETABOLIC              NEUROCOGNITIVE              METHODS & EVIDENCE